"Recurrent Miscarriage Causes: Look Beyond the Woman", this article answered some important questions that I've always had especially about the developing embryo/fetus.
"Methylation Status of the Developing Child
A study from China[2] published in BMC Medicine states “that defects in DNA maintenance methylation in the embryo, not in the mother, are associated with abnormal embryonic implantation and development. The findings of the current study provide new insights into the etiology of early pregnancy loss (EPL). . . . We also found that disturbance of maintenance methylation with a DNMT1 inhibitor may result in a decreased global DNA methylation level and impaired embryonic development in the mouse model, and inhibit in vitro embryo attachment to endometrial cells.”
What does this mean?
This means that methylation in the developing child is directly correlated to a healthy pregnancy outcome – regardless of the methylation status of the mother or father.
What to do?
This article also talks about the importance of the father's genetics and if his MTHFR status affecting the outcome of a pregnancy.
I hope you will find this as interesting as I did. You may be interested in checking out these articles as well, "MTHFR Mutation? Oral Contraceptives Not Recommended" and "How Much Methylfolate Should I Take?".
"Methylation Status of the Developing Child
A study from China[2] published in BMC Medicine states “that defects in DNA maintenance methylation in the embryo, not in the mother, are associated with abnormal embryonic implantation and development. The findings of the current study provide new insights into the etiology of early pregnancy loss (EPL). . . . We also found that disturbance of maintenance methylation with a DNMT1 inhibitor may result in a decreased global DNA methylation level and impaired embryonic development in the mouse model, and inhibit in vitro embryo attachment to endometrial cells.”
What does this mean?
This means that methylation in the developing child is directly correlated to a healthy pregnancy outcome – regardless of the methylation status of the mother or father.
What to do?
- Support methylation in the father and mother prior to, and during, pregnancy in order to increase the odds of optimizing methylation in the developing child.
- Identify genetic defects in the methylation pathway, namely MTHFR, in both parents and supplement accordingly in order to bypass the methylation defect thereby increasing the odds of optimizing methylation in the developing child.
- Identify DNMT inhibitors and have both mother and father cease their use prior to and during pregnancy (for the mother)."
This article also talks about the importance of the father's genetics and if his MTHFR status affecting the outcome of a pregnancy.
I hope you will find this as interesting as I did. You may be interested in checking out these articles as well, "MTHFR Mutation? Oral Contraceptives Not Recommended" and "How Much Methylfolate Should I Take?".
Thanks for sharing this information Jess. I work with NeevoDHA, a prenatal specifically indicated for women with MTHFR. NeevoDHA contains active L-methylfolate as an alternative to synthetic folic acid. L-methylfolate bypasses the MTHFR mutation and is 7 times more bioavailable than folic acid. The role of paternal and fetal methylation status is such a fascinating topic.
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